Role of Hydrogen Peroxide in Cyclosporine-Induced Renal Tubular Cell (LLC-PK1) Injury
نویسندگان
چکیده
منابع مشابه
Gentamicin Induced Apoptosis of Renal Tubular Epithelial (LLC-PK1) Cells
Nephrotoxicity is a major limiting factor in the use of aminoglycoside antibiotics, the mechanisms for which are still speculative. To clarify the mechanisms of renal tubular cell death induced by aminoglycosides, we examined the renal proximal tubule-like cell line, LLC-PK1, after inducing apoptosis through a chronic treatment with gentamicin (GM). Changes in the expression of the Fas were als...
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The current study was designed to test the role of cytochrome P-450 in hydrogen peroxide-induced cytotoxicity, and to determine whether it may serve as a source of catalytic iron. Hydrogen peroxide led to iron release (as measured by iron/bathophenanthroline complex) from the microsomes prepared from LLC-PK1 cells. Cimetidine, which inhibits cytochrome P-450 by interacting with the heme iron, s...
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Nephrotoxicity is one of the important adverse effects induced by cisplatin (CDDP), a potent anticancer drug. CDDP causes a disorder of renal proximal tubules. So, we evaluated mechanisms of renal tubular injury induced by CDDP using established epithelial cell line, LLC-PK1, which is characteristic of renal proximal tubular epithelium. LLC-PK1 cells were incubated in culture media except CDDP ...
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Objective(s): Repaglinide (RG) is an antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus. It has a good safety and efficacy profile in diabetic patients with complications in renal impairment and is an appropriate treatment choice, even for individuals with more severe degrees of renal malfunctions. The aim of the present study was to examine the protective...
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BACKGROUND/OBJECTIVES This study was performed to investigate the in vitro antioxidant and cytoprotective effects of fermented sesame sauce (FSeS) against hydrogen peroxide (H2O2)-induced oxidative damage in renal proximal tubule LLC-PK1 cells. MATERIALS/METHODS 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl radical ((•)OH), and H2O2 scavenging assay was used to evaluate the in vitro antioxid...
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ژورنال
عنوان ژورنال: Journal of Pharmacological Sciences
سال: 2003
ISSN: 1347-8613,1347-8648
DOI: 10.1254/jphs.91.255